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Daily supplementation with green tea extract (GTE) has been shown to favourably influence blood pressure, insulin resistance, inflammation, oxidative stress and lipid profile in patients with obesity-related hypertension. Fifty-six obese, hypertensive subjects were randomised to receive a daily supplement of either 379 mg of GTE or a matching placebo, for three months. At the end of the treatment period, both systolic and diastolic blood pressures had significantly decreased in the GTE group, compared with the placebo group. Significant reductions were also observed in fasting serum glucose, insulin levels and insulin resistance in the GTE group. Serum levels of inflammatory markers (tumour necrosis factor ? and C-reactive protein) were significantly lower, whereas total antioxidant status increased in the treatment group compared with controls. Supplementation also contributed to significant decreases in the total and low-density lipoprotein cholesterol and triglycerides, but an increase in high-density lipoprotein cholesterol. (Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients. Nutr Res. 2012 Jun;32(6):421-7).