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A Chinese pilot study suggests that Chinese herbal medicine (CHM) can reduce dermatological side effects due to treatment with epidermal growth factor receptor (EGFR) inhibitors for lung cancer. Ten lung cancer patients with acne or rashes associated with receiving EGFR inhibitors were treated with CHM three times per day, for three and a half weeks. CHM formulas designed to clear dampness, phlegm and heat (including Zhen Ren Huo Ming Yin, Huang Lian Jie Du Tang, Tuo Li Xiao Du Yin, Wen Qing Yin, Gan Lu Yin and Pi Pa Qing Fei Yin) were prescribed to patients based on their individual presentation. Analysis of the retrospective case series demonstrated a significant decrease in the effects of skin conditions on patients’ quality of life (from 74.5 % at baseline to 19.3 % after treatment). A mean reduction of 82 % in body surface area affected was seen for the distribution of skin lesions after treatment.

Clinical Experience of Chinese Herbal Medicine Ameliorates Dermatologic Events from Epidermal Growth Factor Receptor Inhibitors for Lung Cancer: A Case Series Explore (NY). 2018 Nov 6. pii: S1550-8307(18)30371-9.

 

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