Herbal medicine reduces angina symptoms via effect on inflammation

Chinese herbal medicines with traditional actions described as ‘detoxifying and blood-activating’ can reduce attack frequency and relieve the symptoms of unstable angina, according to Chinese researchers. A total of 144 participants with unstable angina were randomly divided into experimental and control groups. Both groups were treated with standardised drugs for four weeks. The experimental group was additionally treated with a Chinese herbal granule formula, which included Hu Zhang (Rhizoma Polygoni Cuspidati, Japanese knotweed) and Shan Zha (Fructus Crataegi, Hawthorn). In both experimental and control groups, the frequency of weekly angina pectoris attacks was lower after treatment, but no significant intergroup difference was observed.  In the experimental group after the intervention serum levels of inflammatory markers (high-sensitivity C-reactive protein, tumour necrosis factor-α and interleukin-6) decreased, while levels of anti-inflammatory mediators (interleukin-10 and adiponectin) significantly increased. TCM symptoms and syndromes were also ameliorated in the experimental group, showing a significant difference from the control group.

Treating unstable angina with detoxifying and blood-activating formulae: A randomized controlled trial. J Ethnopharmacol. 2021 Dec 5;281:114530.