Herbs perform as well as antipsychotics for tic

Jingxin Zhidong formula (JXZDF), a traditional Chinese medicine, shows similar clinical efficacy to the antipsychotic medication aripiprazole for the treatment of tic disorder (TD). JXZDF is a TCM formula with the traditional action of tranquillising the mind by nourishing the Heart and calming Liver wind and comprises of 13 herbs: Zhen Zhu Mu (Concha Margaritifera), calcined Long Gu (Os Draconis), Mu Li (Concha Ostreae), Suan Zao Ren (Semen Ziziphi Spinosae), Bai Zi Ren (Semen Platycladi), Bai Shao (Radix Paeoniae Alba), Jiang Can (Bombyx Batryticatus), Chai Hu (Radix Bupleuri), Niu Bang Zi (Fructus Arctii), Zhi Qiao (Fructus Aurantii), Dilong (Lumbricus), Chan Tui (Periostracum Cicadae) and Bai Zhi (Angelica Dahurica). In a randomised trial carried out in China, 120 patients with TD, aged 6-16 years, were randomly assigned to receive either JXZDF (17.6 g per day) or aripiprazole (10 mg per day) for 12 weeks. JXZDF demonstrated greater improvements in terms of total tic scores and total motor scores. The difference in rate of improvement between the groups was not significant, although the overall incidence of adverse events was significantly lower in the JXZDF group.

Efficacy of the Jingxin Zhidong Formula for Tic Disorders: A Randomized, Double Blind, Double Dummy, Parallel Controlled Trial. Neuropsychiatr Dis Treat. 2022 Jan 11;18:57-66.